Epithelial sodium channels and hypertension
نویسندگان
چکیده
منابع مشابه
Epithelial sodium channels and hypertension.
Hypertension is a major risk factor for heart attacks, stroke, and kidney failure. It is estimated to cause as many as 25% of all deaths in the United States, particularly for African Americans, in whom the disease is both more common and more severe. Essential hypertension is a multifactorial disorder influenced by both genetic and environmental factors. Physiological studies have shown that t...
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OBJECTIVE To focus on the asthmatic pathogenesis and clinical manifestations related to epithelial sodium channel (ENaC)/chlorine ion channel. DATA SOURCES The data analyzed in this review were the English articles from 1980 to 2015 from journal databases, primarily PubMed and Google Scholar. The terms used in the literature search were: (1) ENaCs; cystic fibrosis (CF) transmembrane conductan...
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Regeneration of the epithelium of mammalian lungs is essential for restoring normal function following injury, and various cells and mechanisms contribute to this regeneration and repair. Club cells, bronchioalveolar stem cells (BASCs), and alveolar type II epithelial cells (ATII) are dominant stem/progenitor cells for maintaining epithelial turnover and repair. Epithelial Na(+) channels (ENaC)...
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The hypothesis that there is a highly conserved, positively charged region distal to the second transmembrane domain in alpha-ENaC (epithelial sodium channel) that acts as a putative receptor site for the negatively charged COOH-terminal beta- and gamma-ENaC tails was tested in mutagenesis experiments. After expression in Xenopus oocytes, alpha-ENaC constructs in which positively charged argini...
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Despite large changes in water and salt intake, the kidney is able to maintain the extracellular osmolarity and volume within narrow margins.1 Such fine control requires specific factors or hormones; among them, aldosterone and vasopressin play key roles. In aldosterone-responsive epithelial cells (kidney, colon), the epithelial sodium channel (ENaC) plays a critical role in the control of sodi...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.189.1